Association of cord blood resistin with leptin, insulin, growth indices and fat levels in neonates of Mousavi hospital of Zanjan in 2009

Resistin is a novel adipokine which may play a role in insulin resistance. In this study we aimed to determine the cord blood resistin, leptin, insulin and maternal serum resistin levels during pregnancy; and to investigate correlation between these metabolic hormones; and also to evaluate their association with newborn growth indices. This study was conducted on 80 newborns and their mothers in Mousavi Hospital Zanjan, Iran in 2009. Newborn growth indices including birth weight, height, body mass index [BMI], Ponderal index, Homeostatic Model assessment [HOMA-IR] and their mothers' BMI were determined. Resistin, leptin and insulin levels were measured by ELISA. In this study, cord blood resistin levels were higher than serum resistin levels of pregnant mothers [10.77 +/- 1.53 vs. 7.91 +/- 5.71 ng/ml]. Moreover, serum resistin levels of mothers' did not exhibit any correlation with cord blood resistin, leptin and insulin levels, as well as neonatal anthropometric indices. Meanwhile, there was no significant correlation between cord resistin levels, insulin resistance, fat percentage and newborn growth factors. Cord resistin levels were positively correlated with cord blood leptin levels [r=0.222; p=0.048]. Also, there was a significant positive correlation between cord blood leptin and neonatal BMI [r=0.223; p=0.047], Ponderal index [r=0.212; p=0.058], HOMA-IR [r=0.426; p=0.052] and fat percentage [r=0.247; p=0.014]. On the basis of the findings, increased cord blood resistin levels may indirectly influence fetal growth through leptin or other cytokine levels. Though, further researches are needed to confirm this matter

[Association of cord blood resistin with leptin, insulin, growth indices and fat levels in neonates of Mousavi hospital of Zanjan in 2009]

Resistin is a novel adipokine which may play a role in insulin resistance. In this study we aimed to determine the cord blood resistin, leptin, insulin and maternal serum resistin levels during pregnancy; and to investigate correlation between these metabolic hormones; and also to evaluate their association with newborn growth indices. This study was conducted on 80 newborns and their mothers in Mousavi Hospital Zanjan, Iran in 2009. Newborn growth indices including birth weight, height, body mass index [BMI], Ponderal index, Homeostatic Model assessment [HOMA-IR] and their mothers. BMI were determined. Resistin, leptin and insulin levels were measured by ELISA. In this study, cord blood resistin levels were higher than serum resistin levels of pregnant mothers [10.77 +/- 1.53 vs. 7.91 +/- 5.71 ng/ml]. Moreover, serum resistin levels of mothers. did not exhibit any correlation with cord blood resistin, leptin and insulin levels, as well as neonatal anthropometric indices. Meanwhile, there was no significant correlation between cord resistin levels, insulin resistance, fat percentage and newborn growth factors. Cord resistin levels were positively correlated with cord blood leptin levels [r=0.222; p=0.048]. Also, there was a significant positive correlation between cord blood leptin and neonatal BMI [r=0.223; p=0.047], Ponderal index [r=0.212; p=0.058], HOMA-IR [r=0.426; p=0.052] and fat percentage [r=0.247; p=0.014]. On the basis of the findings, increased cord blood resistin levels may indirectly influence fetal growth through leptin or other cytokine levels. Though, further researches are needed to confirm this matter

[Predictive value of nucleated red blood cells count in cord blood of newborn]

The screening of infants who need to be admitted immediately following birth but without application of invasive procedures is of prime importance. The aim of this study was to evaluate the value of nucleated red blood cells [nRBCs] count of cord blood in predicting the need for admission to NICU or neonatal ward. This was a case-control study performed on 100 live, newly born full-term infants [70 healthy infants and 30 infants admitted to NICU or neonatal ward] at Vali-e-Asr Hospital of Zanjan [Iran] in 2005. Umbilical cord blood was collected at delivery time to measure the nRBCs count. Data were collected through questionnaires and further analyzed by SPSS using chi square and Mann-Whitney Tests. The mean nRBCs counts in admitted neonates [case group] and healthy infants [control group] failed to show a statistically significant difference however, by omitting the cases for whom negative nRBCs counts were reported, a significant difference between two groups was observed. The number of abnormal nRBCs, the mean number of abnormal nRBCs, and the number of absolute abnormal nRBCs [nRBCs>1000] in cord blood of the case group were significantly higher than those in control group. The sensitivity and specificity of nRBCs count were 33.3% and 100%, respectively. Although the nRBCs count alone could not be considered as an ideal screening tool for those group of neonates with clinical complications however, it seems that the nRBCs count could be a helpful diagnostic parameter in predicting a need for admission